Link: Google Scholar
(*co-first, #co-corresponding)

    In Press

  1. Montague Z*, Lv H*, Otwinowski J, DeWitt WS, Isacchini G, Yip GK, Ng WW, Tsang OTY, Yuan M, Liu H, Wilson IA, Peiris JSM, Wu NC#, Nourmohammad A#, Mok CKP#. Dynamics of B-cell repertoires and emergence of cross-reactive responses in patients with different severities of COVID-19. Cell Reports (In Press).

  2. 2021

  3. Liu H*, Yuan M*, Huang D, Bangaru S, Zhao F, Lee CCD, Peng L, Barman S, Zhu X, Nemazee D, Burton DR, van Gils MJ, Sanders RW, Kornau HC, Reincke SM, Prüss H, Kreye J, Wu NC, Ward AB, Wilson IA. A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection. Cell Host & Microbe 29:806-818.e6 (2021).

  4. Zhou X*, Ma F*, Xie J*, Yuan M*, Li Y*, Shaabani N*, Zhao F, Huang D, Wu NC, Lee CCD, Liu H, Li J, Chen Z, Hong Y, Liu WH, Xiao N, Burton DR, Tu H, Li H, Chen X, Teijaro JR, Wilson IA#, Xiao C#, Huang Z#. Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2. Cell Reports 35:109109 (2021).

  5. Lamers MM, Mykytyn AZ, Breugem TI, Wang Y, Wu DC, Riesebosch S, van den Doel PB, Schipper D, Bestebroer T, Wu NC, Haagmans BL. Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation. eLife 10:e66815 (2021).

  6. Dai L*, Du Y*, Qi H, Huber CD, Chen D, Zhang TH, Wu NC, Wang E, Lloyd-Smith JO, Sun R. Quantifying the Evolutionary Constraints and Potential of Hepatitis C Virus NS5A Protein. mSystems 6:e01111-20 (2021).

  7. Lee CCD*, Watanabe Y*, Wu NC, Han J, Kumar S, Pholcharee T, Seabright GE, Allen JD, Lin CW, Yang JR, Liu MT, Wu CY, Ward AB, Crispin M#, Wilson IA#. A cross-neutralizing antibody between HIV-1 and influenza virus. PLoS Pathogens 17:e1009407 (2021).

  8. Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM#, Wu NC#, Schmidt FI#. Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science 371:eabe6230 (2021).

  9. Yuan M, Liu H, Wu NC, Wilson IA. Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies. Biochemical & Biophysical Research Comm 538:192-203 (2021).

  10. 2020

  11. Liu H*, Wu NC*, Yuan M*, Bangaru S, Torres JL, Caniels TG, van Schooten J, Zhu X, Lee CCD, Brouwer PJM, van Gils MJ, Sanders RW, Ward AB, Wilson IA. Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity. Immunity 53:1272-1280.e5 (2020).

  12. Wu NC*, Yuan M*, Bangaru S*, Huang D*, Zhu X, Lee CD, Turner HL, Peng L, Yang L, Nemazee D, Ward AB#, Wilson IA#. A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody. PLoS Pathogens 16:e1009089 (2020)

  13. Kreye J*, Reincke SM*, Kornau HC, Sánchez-Sendin E, Corman VM, Liu H, Yuan M, Wu NC, Zhu X, Lee CD, Trimpert J, Höltje M, Dietert K, Stöffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Müller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, Prüss H. A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model. Cell 183:1058-1069.e19 (2020).

  14. Wu NC*, Yuan M*, Liu H*, Lee CCD, Zhu X, Bangaru S, Torres JL, Caniels TG, Brouwer PJM, van Gils MJ, Sanders RW, Ward AB, Wilson IA. An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain. Cell Reports 33:108274 (2020).

  15. Wu NC, Wilson IA. Structural biology of influenza hemagglutinin: an amaranthine adventure. Viruses 12:E1053 (2020).

  16. Wu NC*, Andrews SF*, Raab JE, O'Connell S, Schramm CA, Ding X, Chambers MJ, Leung K, Wang L, Zhang Y, Mascola JR, Douek DC, Ledgerwood JE, McDermott AB#, Wilson IA#. Convergent evolution in breadth of two VH6-1-encoded influenza antibody clonotypes from a single donor. Cell Host & Microbe 28:434-444.e4 (2020).

  17. Yuan M*, Liu H*, Wu NC*, Lee CCD, Zhu X, Zhao F, Huang D, Yu W, Hua Y, Tien H, Rogers TF, Landais E, Sok D, Jardine JG, Burton DR, Wilson IA. Structural basis of a shared antibody response to SARS-CoV-2. Science 369:1119-1123 (2020).

  18. Rogers TF*, Zhao F*, Huang D*, Beutler N*, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ramirez S, Ricketts J, Ricciardi MJ, Rawlings SA, Wu NC, Yuan M, Smith DM, Nemazee D, Teijaro JR, Voss JE, Wilson IA, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science 369:956-963 (2020).

  19. Yao Y, Kadam RU, Lee CCD, Woehl JL, Wu NC, Zhu X, Kitamura S, Wilson IA#, Wolan DW#. An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen. PNAS 117:18431-18438 (2020).

  20. Thai E*, Costa G*, Weyrich A*, Murugan R, Oyen D, Flores-Garcia Y, Prieto K, Bosch A, Valleriani A, Wu NC, Pholcharee T, Scally SW, Wilson IA, Wardemann H#, Julien JP#, Levashina EA#. A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity. Journal of Experimental Medicine 217:e20200061 (2020).

  21. Wu NC, Wilson IA. Influenza hemagglutinin structures and antibody recognition. CSH Perspectives in Medicine 10:a038778 (2020).

  22. Lv H, Wu NC#, Mok CKP#. COVID-19 vaccines: knowing the unknown. European Journal of Immunology 50:939-943 (2020).

  23. Wu NC*, Thompson AJ*, Lee JM, Su W, Arlian BM, Xie J, Lerner RA, Yen HL, Bloom JD, Wilson IA. Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses. Science 368:1335-1340 (2020).

  24. Lv H*, Wu NC*, Tsang OTY*, Yuan M, Perera RAPM, Leung WS, So RTY, Chan JMC, Yip GK, Chik TSH, Wang Y, Choi CYC, Lin Y, Ng WW, Zhao J, Poon LLM, Peiris JSM#, Wilson IA#, Mok CKP#. Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections. Cell Reports 31:107725 (2020).

  25. Yuan M*, Wu NC*, Zhu X, Lee CCD, So RTY, Lv H, Mok CKP#, Wilson IA#. A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV. Science 368:630-633 (2020).

  26. Perera RA*, Mok CK*, Tsang OT*, Lv H*, Ko RL, Wu NC, Yuan M, Leung WS, Chan JM, Chik TS, Choi CY, Leung K, Chan KH, Chan KC, Li KC, Wu JT, Wilson IA, Monto AS, Poon LL, Peiris M. Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020. Eurosurveillance 25:2000421 (2020).

  27. Mitchell K*, Brito JJ*, Mandric I*, Wu Q, Knyazev S, Chang S, Martin LS, Karlsberg A, Gerasimov E, Littman R, Hill BL, Wu NC, Yang HT, Hsieh K, Chen L, Littman E, Shabani T, Enik G, Yao D, Sun R, Schroeder J, Eskin E, Zelikovsky A, Skums P, Pop M, Mangul S. Benchmarking of computational error-correction methods for next-generation sequencing data. Genome Biology 21:71 (2020).

  28. Wu NC, Otwinowski J, Thompson AJ, Nycholat CM, Nourmohammad A, Wilson IA. Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape. Nature Communications 11:1233 (2020).

  29. Lin CW, Xie J, Zhang D, Han KH, Grande G, Wu NC, Yang Z, Yea K, Lerner RA. Immunity against cancer cells may promote their proliferation and metastasis. PNAS 117:426-431 (2020).

  30. 2019

  31. Zost SJ, Lee J, Gumina ME, Parkhouse K, Henry C, Wu NC, Lee CCD, Wilson IA, Wilson PC, Bloom JD, Hensley SE. Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans. Cell Reports 29:4460-4470.e8 (2019).

  32. Zhang Y*, Thery F*, Wu NC*, Luhmann EK, Dussurget O, Foecke M, Bredow C, Jiménez-Fernández D, Leandro K, Beling A, Knobeloch KP, Impens F#, Cossart P#, Radoshevich L#. The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection. Nature Communications 10:5383 (2019).

  33. Yuan M*, Cottrell CA*, Ozorowski G*, van Gils MJ, Kumar S, Wu NC, Sarkar A, Torres JL, de Val N, Copps J, Moore JP, Sanders RW, Ward AB#, Wilson IA#. Conformational plasticity in the HIV-1 fusion peptide facilitates recognition by broadly neutralizing antibodies. Cell Host & Microbe 25:873-883.e5 (2019).

  34. Wu NC, Lv H, Thompson AJ, Wu DC, Ng WWS, Kadam RU, Lin CW, Nycholat CM, McBride R, Liang W, Paulson JC, Mok CKP#, Wilson IA#. Preventing an antigenically disruptive mutation in egg-based H3N2 seasonal influenza vaccines by mutational incompatibility. Cell Host & Microbe 25:836-844.e5 (2019).

  35. LaPierre N*, Mangul S*, Alser M, Mandric I, Wu NC, Koslicki D, Eskin E. MiCoP: Microbial Community Profiling method for detecting viral and fungal organisms in metagenomic samples. BMC Genomics 20:423 (2019).

  36. Hong S, Shi Y, Wu NC, Grande G, Douthit L, Wang H, Zhou W, Sharpless KB, Wilson IA, Xie J#, Wu P#. Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification. Nature Communications 10:1799 (2019).

  37. Zost SJ*, Wu NC*, Hensley SE#, Wilson IA#. Immunodominance and antigenic variation of influenza virus hemagglutinin: implications for design of universal vaccine immunogens. The Journal of Infectious Diseases 219:S38-S45 (2019).

  38. Sevy AM, Wu NC, Gilchuk IM, Parrish EH, Burger S, Yousif D, Nagel MBM, Schey KL, Wilson IA, Crowe JE Jr, Meiler J. Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses. PNAS 116:1597-1602 (2019).

  39. Wu NC, Qi H. Application of deep mutational scanning in hepatitis C virus. Methods in Molecular Biology 1911:183-190 (2019).

  40. 2018

  41. Wu NC, Ward AB. Deception through mimicry: a cellular antiviral strategy. Cell 175:1728-1729 (2018).

  42. Credille CV, Dick B, Morrison CN, Stokes RW, Adamek R, Wu NC, Wilson IA, Cohen SM. Structure-activity relationships in metal-binding pharmacophores for influenza endonuclease. Journal of Medicinal Chemistry 61:10206-10217 (2018).

  43. Wu NC, Yamayoshi S, Ito M, Uraki R, Kawaoka Y, Wilson IA. Recurring and adaptable binding motifs in broadly neutralizing antibodies to influenza virus are encoded on the D3-9 segment of the Ig gene. Cell Host & Microbe 24:569-578.e4 (2018).

  44. Lee JM*, Huddleston J*, Doud MB, Hooper KA, Wu NC, Bedford T#, Bloom JD#. Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants. PNAS 115:E8276-E8285 (2018).

  45. Guan W*, Yang Z*, Wu NC*, Lee HHY, Li Y, Jiang W, Shen L, Wu DC, Chen R, Zhong N, Wilson IA, Peiris M, Mok CKP. Clinical correlations of transcriptional profile in patients infected with avian influenza H7N9 virus. The Journal of Infectious Diseases 218:1238-1248 (2018).

  46. Merkouris S, Barde YA, Binley KE, Allen ND, Stepanov AV, Wu NC, Grande G, Lin CW, Li M, Nan X, Chacon-Fernandez P, DiStefano PS, Lindsay RM, Lerner RA#, Xie J#. Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library. PNAS 115:E7023-E7032 (2018).

  47. Wu NC, Thompson AJ, Xie J, Lin CW, Nycholat CM, Zhu X, Lerner RA, Paulson JC, Wilson IA. A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nature Communications 9:1264 (2018).

  48. Wu NC, Wilson IA. Structural insights into the design of novel anti-influenza therapies. Nature Structural & Molecular Biology 25:115-121 (2018).

  49. Du Y, Xin L, Shi Y, Zhang TH, Wu NC, Dai L, Gong D, Brar G, Shu S, Luo J, Reiley W, Tseng YW, Bai H, Wu TT, Wang J, Shu Y, Sun R. Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design. Science 359:290-296 (2018).

  50. 2017

  51. Wu NC, Zost SJ, Thompson AJ, Oyen D, Nycholat CM, McBride R, Paulson JC, Hensley SE, Wilson IA. A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. PLoS Pathogens 13:e1006682 (2017).

  52. Lang S*, Xie J*, Zhu X*, Wu NC, Lerner RA#, Wilson IA#. Antibody 27F3 broadly targets influenza A group 1 and 2 hemagglutinins through a further variation in VH1-69 antibody orientation on the HA stem. Cell Reports 20:2935-2943 (2017).

  53. Du Y*, Chi X*, Wang C, Jiang J, Kong F, Yan H, Wang X, Li J, Wu NC, Dai L, Zhang TH, Shu S, Zhou J, Yoshizawa JM, Li X, Bhattacharya D, Wu TT, Niu J#, Sun R#. Quantifying perinatal transmission of hepatitis B viral quasispecies by tag linkage deep sequencing. Scientific Reports 7:10168 (2017).

  54. Wu NC, Wilson IA. A perspective on the structural and functional constraints for immune evasion: Insights from the influenza virus. Journal of Molecular Biology 429:2694-2709 (2017).

  55. Wright ZVF, Wu NC, Kadam RU, Wilson IA#, Wolan DW#. Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin. Bioorganic & Medicinal Chemistry Letters 27:3744-3748 (2017).

  56. Wu NC*, Xie J*, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA#, Wilson IA#. Diversity of functionally permissive sequences in the receptor-binding site of influenza hemagglutinin. Cell Host & Microbe 21:742-753.e8 (2017).

  57. Wu NC, Grande G, Turner HL, Ward AB, Xie J, Lerner RA, Wilson IA. In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity. Nature Communications 8:15371 (2017).

  58. Lee JH*, Andrabi R*, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, Wilson IA, Burton DR#, Ward AB#. A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic β-hairpin structure. Immunity 46:690-702 (2017).

  59. Xie J, Sok D, Wu NC, Zheng T, Zhang W, Burton DR, Lerner RA. Immunochemical engineering of cell surfaces to generate virus resistance. PNAS 114:4655-4660 (2017).

  60. Qi H, Chu V, Wu NC, Chen Z, Truong S, Brar G, Su SY, Du Y, Arumugaswami V, Olson CA, Chen SH, Lin CY, Wu TT, Sun R. Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein. PNAS 114:2018-2023 (2017).

  61. Artyomenko A*, Wu NC*, Mangul S*, Eskin E, Sun R, Zelikovsky A. Long single-molecule reads can resolve the complexity of the influenza virus composed of rare, closely related mutant variants. Journal of Computational Biology 24:558-570 (2017).

  62. 2016

  63. Du Y, Wu NC, Jiang L, Zhang T, Gong D, Shu S, Wu TT, Sun R. Annotating protein functional residues by coupling high-throughput fitness profile and homologous-structure analysis. mBio 7:e01801-16 (2016).

  64. Wu NC*, Dai L*, Olson CA, Lloyd-Smith JO, Sun R. Adaptation in protein fitness landscapes is facilitated by indirect paths. eLife 5:e16965 (2016).

  65. Zhang TH*, Wu NC*, Sun R. A benchmark study on error-correction by read-pairing and tag-clustering in amplicon-based deep sequencing. BMC Genomics 17:108 (2016).

  66. Wu NC, Olson CA, Sun R. High-throughput identification of protein mutant stability computed from a double mutant fitness landscape. Protein Science 25:530-539 (2016).

  67. Wu NC*, Du Y*, Le S, Young AP, Zhang TH, Wang Y, Zhou J, Yoshizawa JM, Dong L, Li X, Wu TT, Sun R. Coupling high-throughput genetics with phylogenetic information reveals an epistatic interaction on the influenza A virus M segment. BMC Genomics 17:46 (2016).

  68. 2015

  69. York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. Limiting cholesterol biosynthetic flux spontaneously engages type I IFN signaling. Cell 163:1716–1729 (2015).

  70. Qi H*, Wu NC*, Du Y, Wu TT, Sun R. High-resolution genetic profile of viral genomes: why it matters. Current Opinion in Virology 14:62-70 (2015).

  71. Wu NC, Olson CA, Du Y, Le S, Tran K, Remenyi R, Gong D, Al-Mawsawi LQ, Qi H, Wu TT, Sun R. Functional constraint profiling of a viral protein reveals discordance of evolutionary conservation and functionality. PLoS Genetics 11:e1005310 (2015).

  72. 2014

  73. Al-Mawsawi LQ, Wu NC, Olson C, Shi V, Qi H, Zheng X, Wu TT, Sun R. High-throughput profiling of point mutations across the HIV-1 genome. Retrovirology 11:124 (2014).

  74. Olson CA, Wu NC, Sun R. A comprehensive biophysical description of pairwise epistasis throughout an entire protein domain. Current Biology 24:2643-2651 (2014).

  75. Remenyi R*, Qi H*, Su SY, Chen Z, Wu NC, Arumugaswami V, Truong S, Chu V, Stokelman T, Lo HH, Olson CA, Wu TT, Chen SH, Lin CY, Sun R. A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. mBio 5:e01469-14 (2014).

  76. Gong D, Wu NC, Xie Y, Feng J, Tong L, Brulois KF, Luan H, Du Y, Jung JU, Wang CY, Kang MK, Park NH, Sun R, Wu TT. Kaposi's sarcoma-associated herpesvirus ORF18 and ORF30 are essential for late gene expression during lytic replication. Journal of Virology 88:11369-11382 (2014).

  77. Wu NC, Young AP, Al-Mawsawi LQ, Olson CA, Feng J, Qi H, Luan HH, Li X, Wu TT, Sun R. High-throughput identification of loss-of-function mutations for anti-interferon activity in the influenza A virus NS segment. Journal of Virology 88:10157-10164 (2014).

  78. Mangul S*, Wu NC*, Mancuso N, Zelikovsky A, Sun R, Eskin E. Accurate viral population assembly from ultra-deep sequencing data. Bioinformatics 30:i329-i337 (2014).

  79. Al-Mawsawi LQ*, Wu NC*, De La Cruz J, Shi VC, Wu TT, Daar ES, Lewis MJ, Yang OO, Sun R. Short communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing. AIDS Research and Human Retroviruses 30:806-811 (2014).

  80. Wu NC, De La Cruz J, Al-Mawsawi LQ, Olson CA, Qi H, Luan HH, Nguyen N, Du Y, Le S, Wu TT, Li X, Lewis MJ, Yang OO, Sun R. HIV-1 quasispecies delineation by tag linkage deep sequencing. PLoS One 9:e97505 (2014).

  81. Wu NC*, Young AP*, Al-Mawsawi LQ, Olson CA, Feng J, Qi H, Chen SH, Lu IH, Lin CY, Chin RG, Luan HH, Nguyen N, Nelson SF, Li X, Wu TT, Sun R. High-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolution. Scientific Reports 4:4942 (2014).

  82. Feng J, De Jesus PD, Su V, Han S, Gong D, Wu NC, Tian Y, Li X, Wu TT, Chanda SK, Sun R. RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production. Journal of Virology 88:7987-7997 (2014).

  83. Le S, Yao X, Lu S, Tan Y, Rao X, Li M, Jin X, Wang J, Zhao Y, Wu NC, Lux R, He X, Shi W, Hu F. Chromosomal DNA deletion confers phage resistance to Pseudomonas aeruginosa. Scientific Reports 4:4738 (2014).

  84. Qi H, Olson CA, Wu NC, Ke R, Loverdo C, Chu V, Truong S, Remenyi R, Chen Z, Du Y, Su SY, Al-Mawsawi LQ, Wu TT, Chen SH, Lin CY, Zhong W, Lloyd-Smith JO, Sun R. A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity. PLoS Pathogens 10:e1004064 (2014).

  85. Ke R, Loverdo C, Qi H, Olson CA, Wu NC, Sun R, Lloyd-Smith JO. Modelling clinical data shows active tissue concentration of daclatasvir is 10-fold lower than its plasma concentration. Journal of Antimicrobial Chemotherapy 69:724-727 (2014).

  86. 2013

  87. Wu NC*, Young AP*, Dandekar S, Wijersuriya H, Al-Mawsawi LQ, Wu TT, Sun R. Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening. Journal of Virology 87:1193-1199 (2013).

  88. 2011

  89. Wu N, Yang X, Li L. Identification of feed forward loops composed of microRNAs and transcription factors in arabidopsis. Journal of Biochemistry and Molecular Biology in the Post Genomic Era 1:79-85 (2011).

  90. 2010

  91. He H, Zhang H, Wang X, Wu N, Yang X, Chen R, Li Y, Deng XW, Li L. Development of a versatile, target-oriented tiling microarray assay for measuring allele-specific gene expression. Genomics 96:308-315 (2010).